Stimulation of Rho signaling by pathologic mechanical stretch is a “ second 1 hit ” to Rho - independent lung injury induced by IL - 6 2 3 4 5 6 Anna
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چکیده
Stimulation of Rho signaling by pathologic mechanical stretch is a “second 1 hit” to Rho-independent lung injury induced by IL-6 2 3 4 5 6 Anna A. Birukova, Yufeng Tian, Angelo Meliton, Alan Leff, Tinghuai Wu, and 7 Konstantin G. Birukov 8 9 Lung Injury Center, Section of Pulmonary and Critical Medicine, Department of 10 Medicine, University of Chicago, Chicago, Illinois 60637, USA 11 12 13 Running title: Mechanical factors and lung inflammation 14 15
منابع مشابه
Stimulation of Rho signaling by pathologic mechanical stretch is a "second hit" to Rho-independent lung injury induced by IL-6.
Most patients with acute lung injury (ALI) and acute respiratory distress syndrome of septic and nonseptic nature require assisted ventilation with positive pressure, which at suboptimal range may further exacerbate lung dysfunction. Previous studies described enhancement of agonist-induced Rho GTPase signaling and endothelial cell (EC) permeability in EC cultures exposed to pathologically rele...
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تاریخ انتشار 2012